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wistar han rats

Chronic prostatitis characterized on light microscopic examination by moderate, multifocal, predominantly lymphocytic inflammation associated with epithelial atypia and … 1998). Origin: Derived at Biological Research Laboratories Limited (BRL), formerly RCC, now Harlan Laboratories Ltd., Füllinsdorf, Switzerland from original colony at Zentralinstitute für Versuchstierzucht, Hannover in 1989. Wistar Han Rats in the Two-year Gavage Study of Tetrabromobisphenol A .....37 Table 7. Multivariate t-pattern analyses demonstrated a very different temporal profile of behavior in the two strains: Wistar rats presented 197 t-patterns of different composition, whereas DA/Han rats only 26; as to the mean number of t-patterns, Wistar presented a value of 698.90, whereas DA/Han only 92.80. At gestation day (GD) 6, pregnant dams were provided acrylamide in their drinking water. 2012 Sep;34(2):192-203. doi: 10.1016/j.reprotox.2012.05.091. Epub 2018 May 31. rats [14], but published historical data on wistar Han-nover rats relating to a general toxicity study are scarce [21]. OYEYEMI, M. O. Each member of GALAS received 50 breeding stock from RCC in 1998. Not all people looking for information on Wistar Rats are looking for information on Lab Rats in general, not to mention an image of a dissected one. Taconic replaced its previous Wistar Hannover stock with Wistar Hannover … Table III. therefore, collection of general toxico-(Received 23 August 2011 / … Differences in Types and Incidence of Neoplasms in Wistar Han and Sprague-Dawley Rats. 1. Furthermore, concern has been expressed that children might be at higher risk to acrylamide due to Int. The selection of your animal model for toxicity and carcinogenicity testing plays an essential role in the accuracy of your study findings. Furthermore, age-related changes and sex differ-ences in serum chemistry values in sd rats have been reported [18]. [Amy Zmarowski, Manon Beekhuijzen, Joost Lensen, Harry Emmen] PMID 22664268 [ Wistar Institute] and Wistar Han rats, and WBC and AST were lower than those in the ad libitum fed SD rats. The rats were refreshed with cryopreserved embryos in 1998. Arch Toxicol. It has the distinct honor of being the first rat stock developed to serve as a model animal. Use an outbred stock of rat such as the Wistar Han or the Sprague Dawley NTP temporarily switched to the F344/NTac rat and then selected the Wistar Han rat [Crl:WI (Han)]. Wistar Han rats were selected due to their longevity and low incidence of Leydig cell tumors. One conventional 2-fed female rat developed a pituitary haemangioma and one 11 % GMO-fed female rat a yolk sac carcinoma, a rare spontaneous neoplasm of germ cell origin (Sobis 1987 ; Nakazawa et al. Wistar Institute (USA) Han Wistar breeding movement Wistar breeding movement 1995 2004 1982 1968 1989 1994 1993 1996 The Wistar Hannover source colony was originally ... Wistar Hannover rats make it an exceptional strain for carcinogenicity testing, relative to … While developmental exposure to TCDD has toxic effects, our data have shown no potent adverse effects on epididymal sperm levels or the weights of accessory sex organs. In both strains, females were more affected, but the sex difference was Table 1: Incidence and cellular distribution of pigment deposits in the liver of Han Wistar rats in short term studies. As a result, body weights and food consumption in Wistar Han rats were lower than those of SD rats. We report here the oncogenic response of Wistar Han rats to orally administered acrylamide. Based on these results, some strain differences might be ascribable to reduced food consumption and associated body weight changes in Wistar Han rats. Toxicol Pathol. Han/Wistar (Kuopio ) rats have a mutated AhR (AhR hw/hw) while Long‐Evans rats have wild type AhR (AhR wt/wt) (Pohjanvirta et al . Popularity of Han Wistar rats – reproductive toxicity studies UK* Studies completed 2009 – 2013 * Main plus preliminary studies combined count. Ninety-day oral toxicity studies on two genetically modified maize MON810 varieties in Wistar Han RCC rats (EU 7th Framework Programme project GRACE). Differential performance of Wistar Han and Sprague Dawley rats in behavioral tests: differences in baseline behavior and reactivity to positive control agents. The data from Wistar Han rats were compared with those from Sprague Dawley Crl:CD(SD) rats. Sperm positive female Wistar Han/RccHan:WIST rats were obtained from Harlan Laboratories GmbH, Serumweg 48, 27324 Eystrup, Germany in multiple deliveries. Differential performance of Wistar Han and Sprague Dawley rats in behavioral tests: differences in baseline behavior and reactivity to positive control agents Reprod Toxicol . occurs more commonly in Han Wistar rats. Morphol., 27(1):7-11, 2009. Survival and Body Weights of Mice in the Three-month Gavage Study of Taconic received breeding stock from RCC in 1998. Incidences of Neoplasms and Non-neoplastic Lesions of the Testis and Ovary in Wistar Han Rats in the Two-year Gavage Study of Tetrabromobisphenol A .....40 Table 8. An outbred Wistar rat strain (CRL:WI(Han)) was used to ensure comparability with (1) previous use of Wistar rats (Faqi et al., 1998) and (2) extensive in-house experience with this strain. The substrains of Wistar rats: Wistar Hannover (Han/Wistart) and Wistar Unilever (WU) rat are outbred; while Wistar Kyoto and Wistar … & ADENIJI, D. A. Morphological characteristics and haematological studies in Wistar rats subjected to prolonged treatment of chloramphenicol. Wistar rats: ( wis'tehr ), an inbred strain of rats, homozygous at most loci, produced by strict brother-sister inbreeding over many generations to develop animals for research with the same general genetic composition. Our researchers recently completed a two-year study of 130 male and 130 female Envigo RccHan®:WIST (Wistar Han®) rats and compared them to other outbred rats (e.g., Sprague-Dawley®, Fischer 344).Here, we share the results of the study. Prevalence and influence of cys407* Grm2 mutation in Hannover-derived Wistar rats: mGlu2 receptor loss links to alcohol intake, risk taking and emotional The data that have been presented for Wistar strains show a lower incidence of fibroadenoma in Crl: WI(Han) rats when compared to RccHan ™: WIST rats. In addition, the effects of restricted feeding of SD rats were also investigated by one facility. Average and Range Weights Male and Female Wistar and Sprague Dawley Rats from 3 to 12 Weeks held at ARC (updated yearly) Average and Range of Weights (g) of Commonly Used Strains of Mice* Key words:Wistar Hannover rat, Sprague Dawley rat, Background data, General toxicity J. The study design, the performance and the results of the feeding trials Table 1 Maize variety content of the different diets used in the rat feeding trials D and E aNear-isogenic maize variety of DKC6667 YG, from Monsanto Toxicity of 2,3,7,8-Tetrachlorodibenzo-p-dioxin in the Developing Male Wistar(Han) Rat. 2011 ). Outbred Rats - RccHan:WIST - 168. Morphological aberration in Control and Treated Groups. Both the incidence and severity of this change were higher in Han Wistar than in Sprague-Dawley rats. Two rats succumbed in the course of the experiment: one in the group receiving 625 and one dosed 1000 μg/kg. 2018 Jul;92(7):2385-2399. doi: 10.1007/s00204-018-2230-z. The incidence of adenocarcinoma, while higher in SD strains, varies dramatically between different SD strains/suppliers, with approximately 22% reported in Crl: CD(SD) rats ( Charles River 2004 ) compared with 13% in Hsd: SD rats … 5-week-old male and female Wistar Han RCC rats were pur - chased from Harlan (San Pietro al Natisone, Italy). We report here the oncogenic response of Wistar Han rats to orally administered acrylamide. Wistar Han RCC rats at the end of both feeding trials The mycotoxins fumonisin B1, fumonisin B2 and deox- reached a value of about 410–430 g/animal, while that of ynivalenol were detected in some of the diets, although at the female rats was about 250 g/animal. II: Chronic Dosing Causes Developmental Delay Table II. To explain this apparent sex-dependence, the disposition and toxicokinetic profile of TBBPA were investigated using female Wistar Han rats, as no data were available for female rats. Humoral and cellular immune response in Wistar Han RCC rats fed two genetically modified maize MON810 varieties for 90 days (EU 7th Framework Programme project GRACE). Furthermore, concern has been expressed that children might be at higher risk to acrylamide due to greater dietary acrylamide intake (EPA Science Advisory Board, 2008). Wistar Han rats were selected due to their longevity and low incidence of Leydig cell tumors. Differences in the incidences of fetal malformations have also been shown to occur between Han/Wistar (Kuopio ) rats and Long‐Evans rats …

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